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Orbital Tumors

Determining Your Prognosis

Your prognosis is a prediction of the outcome of your disease. What is the risk of succumbing to the cancer or the risk of its coming back? These are the big questions on most people’s minds after receiving a diagnosis of head and neck cancer.

It is very difficult to discuss prognosis without understanding all the details of your cancer, and this is a conversation you’re better off having in person with your doctor. To give you a percentage chance of cure is really difficult because cancer research looks at all sorts of different types of cancers and may include patients from long ago.

There is relatively little data about these rare orbital cancers. However, there are a few studies that give doctors an idea of what to expect.

A large collaboration called the Intergroup Rhabdomyosarcoma Study Group (IRSG) follows and studies the best treatments for rhabdomyosarcomas in the U.S. An interesting study that combined IRSG as well as three international rhabdomyosarcoma study groups found a relatively good survival rate for orbital rhabdomyosarcoma. At 10 years, overall survival was 87 percent, even though there was a difference in how many patients received radiation therapy.14 Oberlin O, Rey A, Anderson J, Carli M, Raney RB, Treuner J, Stevens, MC. Treatment of orbital rhabdomyosarcoma: survival and late effects of treatment—results of an international workshop. Journal of clinical oncology. 2001;19(1),197-204.

For lacrimal cancers the percentage of people alive five years after diagnosis (overall survival) ranges from 40 to 80 percent.7 Skinner HD, Garden AS, Rosenthal DI, Ang KK, Morrison WH, Esmaeli B, Pinnix CC, Frank SJ. Outcomes of Malignant Tumors of the Lacrimal Apparatus: The University of Texas MD Anderson Cancer Center Experience. Cancer. 2011;117(12):2801-2810.

References

1 Riedel KG, Markl A, Hasenfratz G, Kampik A, Stefani FH, Lund OE. Epithelial tumors of the lacrimal gland: clinico-pathologic correlation and management. Neurosurg Rev. 1990;13(4):289-98.

2 Tijl JW, Koornneef L. Fine needle aspiration biopsy in orbital tumours. Br J Ophthalmol.1991 August;75(8):491-492.

3 Spiro RH, Thaler HT, Hicks WF, Kher UA, Huvos AH, Strong EW. The importance of clinical staging of minor salivary gland carcinoma. Am J Surg. 1991 Oct;162(4):330-6.

4 Smitt, MC, Donaldson SS. Radiotherapy is successful treatment for orbital lymphoma. International Journal of Radiation Oncology*Biology*Physics. 1993;26(1):59-66.

5 Bolek TW, Moyses HM, Marcus Jr RB, Gorden III L, Maiese RL, Almasri NM, Mendenhall NP. Radiotherapy in the management of orbital lymphoma. International Journal of Radiation Oncology*Biology*Physics. Volume 44, Issue 1, 1 April 1999;31-36.

6 Goldberg RA, Rootman J. Clinical characteristics of metastatic orbital tumors. Ophthalmology. 1990 May;97(5):620-4.

7 Skinner HD, Garden AS, Rosenthal DI, Ang KK, Morrison WH, Esmaeli B, Pinnix CC, Frank SJ. Outcomes of Malignant Tumors of the Lacrimal Apparatus: The University of Texas MD Anderson Cancer Center Experience. Cancer. 2011;117(12):2801-2810.

8 Wright J, Rose G, Garner A. Primary malignant neoplasms of the lacrimal gland. Br J Ophthalmology. 1992;76:401-407.

9 Kim M, Park K, Kim JH, Kim Y, Lee J. Gamma knife radiosurgery for orbital tumors. Clin Neurol Neurosurg. 2008;110:1003-1007.

10 Douglas JG, Laramore GE, Austin-Seymour M, et al. Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy. Int J Radiat Oncol Biol Phys. 2000;46:551-557.

11 Finger PT. Radiation Therapy for Orbital Tumors: Concepts, Current Use, and Ophthalmic Radiation Side Effects, Survey of Ophthalmology. Volume 54, Issue 5, September–October 2009;545-568.

12 Meel R, Pushker N, Bakhshi S. Adjuvant chemotherapy in lacrimal gland adenoid cystic carcinoma. Pediatr Blood Cancer. 2009;53:1163-1164.

13 Meldrum ML, Tse DT, Benedetto P. Neoadjuvant intracarotid chemotherapy for treatment of advanced adenocystic carcinoma of the lacrimal gland. Arch Ophthalmol. 1998;116:315-321.

14 Oberlin O, Rey A, Anderson J, Carli M, Raney RB, Treuner J, Stevens, MC. Treatment of orbital rhabdomyosarcoma: survival and late effects of treatment—results of an international workshop. Journal of clinical oncology. 2001;19(1),197-204.